The effect of aprotinin on postlaminectomy peridurat fibrosis in 20 farm,rabbits was studied in this prelimi-nary study. Laminectomies were performed at two different level (L2 and La) in 20 rabbits. absorbable sponge soaked with aprotinin or phosphate buffered şaline (PBS) was applied in a double-blind fashion to the opera-tive sites in rabbit. Animals were killed after 2 or 4 weeks. The extent of peridural fibrosis was evaluated by gross microdissection and histological analysis. İt was shown that aprotinin reduced the peridural fibrosis after laminectomy.
Keywords: Aprotinin, laminectomy, peridural fibrosis, rabbit.